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2.1 Mechanistic evidence of natural compounds Preclinical studies have demonstrated that these natural products modulate multiple AD-related pathways including reducing A burden, inhibiting tau hyperphosphorylation, preserving mitochondrial function, and suppressing pro-inflammatory cytokines (Wang et al., 2022b)

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This further indicated that a high-cholesterol diet may damage vascular endothelium by affecting the NO/cGMP pathway, thereby reducing erectile function [131]

In addition to the VHL-HIF-VEGF/vascular endothelial growth factor receptor (VEGFR) pathway, VHL mutations affect signaling regulation in the mTOR and epidermal growth factor receptor (EGFR) pathways, promoting tumor growth (130)

I.CuzicS.BrajsaK.MildnerB.BokulicA.SitumK.et al (2007)